I really had high hopes for Cosentyx (IL-17) working for me after Enbrel started diminishing in effectiveness. After 8 weeks, all of my prior involved joints are inflamed and hurting and now I have new ones acting up. Can barely stand up, walk or even type this. The fatigue is just unbelievable…sleeping 10+ hours per days but still exhausted. I’m worse than before I started biologics. My inflammatory marker labs are going off the chart. I don’t think they have ever been this high. They were going up anyway on the Enbrel but this is now double and triple the values from my last Enbrel lab work.
On the plus side, my skin (except for my scalp) is fabulous. Cyndi Lauper was correct about having clearer skin. It hasn’t been this clear since I was on Humira. According to the old SNL skit, it is better to look good than to feel good, and I look mahr-vah-lussss. But truthfully, I would rather feel good.
I see the doctor tomorrow afternoon and trying to figure out which med to try next. Because Taltz is also IL-17, I’m ruling that one out. Also avoiding Xeljanz due to concern about blood clots. I would like to try a TNF biosimilar but those are all apparently still blocked by patent lawsuits in the good old USA. What an awful healthcare system- profits over people!
What I’ve tried so far:
Methotrexate - unable to tolerate side effects, no improvement
Humira - worked great joints and skin but rejected (Humira flu) after about 6 months
Enbrel - never worked as good as Humira but fair control that was diminishing over time
Cosentyx - failed as above.
I’m concerned about the side effects but I’m leaning toward Otezla or possibly Stelara.